Brazilian Archives of Biology and Technology (Feb 2011)

Alkaloids and triterpene from Almeidea coerulea (Nees and Mart.) a. St.-Hil. and anti-leishmanial activity

  • Lucia Elaine Ranieri Cortez,
  • Izabel Cristina Piloto Ferreira,
  • Valdrinez Campana Lonardoni,
  • Antonio Gilberto Ferreira,
  • Paulo Cesar Vieira,
  • Maria Fátima das Graças Fernandes da Silva,
  • João Batista Fernandes,
  • Diógenes Aparicio Garcia Cortez

DOI
https://doi.org/10.1590/S1516-89132011000100008
Journal volume & issue
Vol. 54, no. 1
pp. 61 – 66

Abstract

Read online

The dichloromethane extract of Almeidea coerulea stems yielded the (11-hydroxyrutaecarpine alkaloid reported for the first time from this species) and the triterpene (28-hydroxy-28, 29-dihydrolupeol). The dictamine, skimianine, sitosterol and stigmasterol were also isolated from methanol extract. Extracellular forms of Leishmania amazonensis (promastigotes) was tested with dichloromethane extract and 28-hydroxy-28, 29-dihydrolupeol with showed anti-leishmanial activity above 0.1 mg/mL and 75µg/mL (inhibited 50% promastigote growth), respectively.

Keywords