Biosensor Time Response and Noise Models That Take into Account Spatial Rearrangement of Adsorbed Biomolecules

Abstract

In order to improve biosensor performance, it is important to develop mathematical models of sensors’ temporal response and noise, which include the effects of processes and phenomena relevant to the real applications of these devices. Here, we present a novel, more comprehensive response and noise models that consider the rearrangement process of biomolecules upon their adsorption on the sensing surface. We evaluate the extent of the influence of this process for various rates of rearrangement and adsorption–desorption processes. The development of such models is indispensable for the correct interpretation of the measurement results and also for the estimation and improvement of sensor performance limits, yielding the more reliable detection of the target agent in the analyzed samples.

Keywords

• sensor noise
• sensor time response
• adsorption
• biomolecular rearrangement
• protein conformation
• protein sensor