Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors

Txomin Lalanne; Julia Oyrer; Mark Farrant; P. Jesper Sjöström

doi:10.3389/fnsyn.2018.00034

Frontiers in Synaptic Neuroscience (Oct 2018)

Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors

Txomin Lalanne,
Julia Oyrer,
Mark Farrant,
P. Jesper Sjöström

Affiliations

Txomin Lalanne: Department of Biomedicine, Institute of Physiology, University of Basel, Basel, Switzerland
Julia Oyrer: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia
Mark Farrant: Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
P. Jesper Sjöström: Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Brain Repair and Integrative Neuroscience Program, Montreal General Hospital, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada

DOI: https://doi.org/10.3389/fnsyn.2018.00034
Journal volume & issue: Vol. 10

Abstract

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Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy.

Published in Frontiers in Synaptic Neuroscience

ISSN: 1663-3563 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/synaptic-neuroscience

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Abstract

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