Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury

Yufeng Xi; Guang Yue; Shuqiang Gao; Rong Ju; Yujia Wang

doi:10.1186/s13287-022-03153-y

Stem Cell Research & Therapy (Sep 2022)

Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury

Yufeng Xi,
Guang Yue,
Shuqiang Gao,
Rong Ju,
Yujia Wang

Affiliations

Yufeng Xi: Department of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Guang Yue: Department of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Shuqiang Gao: Department of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Rong Ju: Department of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Yujia Wang: Department of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China

DOI: https://doi.org/10.1186/s13287-022-03153-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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Abstract Perinatal brain injury is a leading cause of death and disability in children. Hypoxic-ischemic encephalopathy in full term infants, and white matter injury in premature infants are most known brain injury in perinatal period. Human umbilical cord blood mononuclear cells contain hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, lymphocytes, monocytes, and so on. Human umbilical cord blood mononuclear cells have many biological functions, such as nerve and vascular regeneration, anti-apoptosis, anti-inflammation, and immune regulation. Human umbilical cord blood mononuclear cells transplantation has achieved significant efficacy and safety in animal and clinical trials for the treatment of perinatal brain injury. We will review human umbilical cord blood mononuclear cells transplantation for perinatal brain injury in this review.

Published in Stem Cell Research & Therapy

ISSN: 1757-6512 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General); Science: Chemistry: Organic chemistry: Biochemistry
Website: https://stemcellres.biomedcentral.com

About the journal

Abstract

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