Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

Arthur C. Sletten; Jessica W. Davidson; Busra Yagabasan; Samantha Moores; Michaela Schwaiger-Haber; Hideji Fujiwara; Sarah Gale; Xuntian Jiang; Rohini Sidhu; Susan Gelman; Shuang Zhao; Gary Patti; Daniel S. Ory; Jean E. Schaffer

doi:10.1038/s41467-021-25457-y

Nature Communications (Sep 2021)

Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

Arthur C. Sletten,
Jessica W. Davidson,
Busra Yagabasan,
Samantha Moores,
Michaela Schwaiger-Haber,
Hideji Fujiwara,
Sarah Gale,
Xuntian Jiang,
Rohini Sidhu,
Susan Gelman,
Shuang Zhao,
Gary Patti,
Daniel S. Ory,
Jean E. Schaffer

Affiliations

Arthur C. Sletten: Department of Medicine, Washington University in St. Louis
Jessica W. Davidson: Joslin Diabetes Center, Harvard Medical School
Busra Yagabasan: Joslin Diabetes Center, Harvard Medical School
Samantha Moores: Joslin Diabetes Center, Harvard Medical School
Michaela Schwaiger-Haber: Department of Chemistry, Washington University in St. Louis
Hideji Fujiwara: Department of Medicine, Washington University in St. Louis
Sarah Gale: Department of Medicine, Washington University in St. Louis
Xuntian Jiang: Department of Medicine, Washington University in St. Louis
Rohini Sidhu: Department of Medicine, Washington University in St. Louis
Susan Gelman: Department of Chemistry, Washington University in St. Louis
Shuang Zhao: Department of Medicine, Washington University in St. Louis
Gary Patti: Department of Chemistry, Washington University in St. Louis
Daniel S. Ory: Department of Medicine, Washington University in St. Louis
Jean E. Schaffer: Joslin Diabetes Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-021-25457-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

Read online

Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects against steatohepatitis in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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