Nature Communications (May 2020)

Cooperative transport mechanism of human monocarboxylate transporter 2

  • Bo Zhang,
  • Qiuheng Jin,
  • Lizhen Xu,
  • Ningning Li,
  • Ying Meng,
  • Shenghai Chang,
  • Xiang Zheng,
  • Jiangqin Wang,
  • Yuan Chen,
  • Dante Neculai,
  • Ning Gao,
  • Xiaokang Zhang,
  • Fan Yang,
  • Jiangtao Guo,
  • Sheng Ye

DOI
https://doi.org/10.1038/s41467-020-16334-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Proton-linked monocarboxylate transporters (MCTs) facilitate monocarboxylate efflux in glycolytically active cells and regulate transport down in glycolytically inactive cells. Here authors show a steep dependence of human MCT2 activity on substrate concentration and show the structural basis of cooperative transport.