Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report

Abstract

Abstract Background To the best of our knowledge, this case represents the first report of an extranodal double-hit follicular lymphoma (DH-FL) as an intestinal polypoid lesion. Case presentation A 72-year-old woman presents with constipation. Colonoscopy reveals a sessile polypoid lesion of the colon bearing morphological, immunohistochemical and molecular hallmarks of DH-FL. Complete clinical staging and bone marrow biopsy showed no signs of disseminated disease. The patient, after two years of follow-up is still free of disease confirming the indolent behaviour of this limited lesion. Conclusions A synoptic view at all the features of the patient and not merely at the molecular hallmarks of a disease are essential to establish the correct clinical approach.

Keywords

• Colonoscopy
• Gastrointestinal lymphoma
• Follicular lymphoma
• Double-hit follicular lymphoma
• Case report