Clinical ocular prediction model of postoperative ametropic amblyopia in patients with congenital ectopia lentis

Xinyue Wang; Xinyue Wang; Xinyue Wang; Linghao Song; Linghao Song; Linghao Song; Yan Liu; Yan Liu; Yan Liu; Qiuyi Huo; Qiuyi Huo; Qiuyi Huo; Yang Sun; Yang Sun; Yang Sun; Zexu Chen; Zexu Chen; Zexu Chen; Wannan Jia; Wannan Jia; Wannan Jia; Xin Shen; Xin Shen; Xin Shen; Yalei Wang; Yalei Wang; Yalei Wang; Xinyao Chen; Xinyao Chen; Xinyao Chen; Tianhui Chen; Tianhui Chen; Tianhui Chen; Yongxiang Jiang; Yongxiang Jiang; Yongxiang Jiang; Rui Wang

doi:10.3389/fmed.2024.1491736

Frontiers in Medicine (Oct 2024)

Clinical ocular prediction model of postoperative ametropic amblyopia in patients with congenital ectopia lentis

Xinyue Wang,
Xinyue Wang,
Xinyue Wang,
Linghao Song,
Linghao Song,
Linghao Song,
Yan Liu,
Yan Liu,
Yan Liu,
Qiuyi Huo,
Qiuyi Huo,
Qiuyi Huo,
Yang Sun,
Yang Sun,
Yang Sun,
Zexu Chen,
Zexu Chen,
Zexu Chen,
Wannan Jia,
Wannan Jia,
Wannan Jia,
Xin Shen,
Xin Shen,
Xin Shen,
Yalei Wang,
Yalei Wang,
Yalei Wang,
Xinyao Chen,
Xinyao Chen,
Xinyao Chen,
Tianhui Chen,
Tianhui Chen,
Tianhui Chen,
Yongxiang Jiang,
Yongxiang Jiang,
Yongxiang Jiang,
Rui Wang

Affiliations

Xinyue Wang: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Xinyue Wang: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Xinyue Wang: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Linghao Song: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Linghao Song: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Linghao Song: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Yan Liu: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Yan Liu: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Yan Liu: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Qiuyi Huo: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Qiuyi Huo: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Qiuyi Huo: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Yang Sun: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Yang Sun: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Yang Sun: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Zexu Chen: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Zexu Chen: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Zexu Chen: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Wannan Jia: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Wannan Jia: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Wannan Jia: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Xin Shen: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Xin Shen: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Xin Shen: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Yalei Wang: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Yalei Wang: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Yalei Wang: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Xinyao Chen: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Xinyao Chen: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Xinyao Chen: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Tianhui Chen: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Tianhui Chen: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Tianhui Chen: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Yongxiang Jiang: Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
Yongxiang Jiang: NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
Yongxiang Jiang: Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
Rui Wang: Department of Ophthalmology, The First Affiliated Hospital of Northwest University, Xi’an, China

DOI: https://doi.org/10.3389/fmed.2024.1491736
Journal volume & issue: Vol. 11

Abstract

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IntroductionDespite prompt and appropriate surgical management, a considerable proportion of patients with congenital ectopia lentis (CEL) suffer from postoperative ametropic amblyopia. To predict and identify at-risk patients early, and ensure timely amblyopia treatment, we conducted a thorough investigation into the onset and progression patterns of postoperative amblyopia in patients with CEL. Moreover, an ocular prediction model was constructed for amblyopia.MethodsIn this prospective cohort study, amblyopia analysis was conducted to reveal the prevalence of postoperative amblyopia at different time points of follow-up. Comparative analysis and logistic regression analysis were performed for the development of an amblyopia prediction model. Receiver Operating Characteristic (ROC) analysis, calibration plots, and decision curve analysis (DCA) were used to evaluate the performance of the model. A nomogram was created to determine the probability of postoperative amblyopia. Amblyopia was diagnosed according to the most recent edition of the Amblyopia Preferred Practice Pattern.ResultsA total of 889 eyes from 677 patients operated for CEL were enrolled in this study. In the pediatric cohort, the prevalence of amblyopia showed a decreasing trend with follow-up time from 1 month to 3.5 years. A prediction model based on preoperative best-corrected visual acuity (BCVA) and cardiac phenotype was established to predict postoperative amblyopia. For effective individual prediction, a nomogram was created. With great calibration, discrimination, and clinical usefulness, the prediction model demonstrated good performance.ConclusionThe findings underscore that the prevalence of ametropic amblyopia in pediatric CEL patients who underwent lens surgery exhibited a marked decline over time. The prediction model established with preoperative BCVA and cardiac phenotype can provide accurate and individualized predictions of postoperative amblyopia, and it has the potential to assist ophthalmologists in rapidly identifying high-risk patients.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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