Relationship Between Time in Range and Dusk Phenomenon in Outpatients with Type 2 Diabetes Mellitus

Abstract

Xiangyu Gao,* Hongmei Li,* Yuan Yu, Xiaoyuan Huai, Bo Feng, Jun Song Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Song; Bo Feng, Department of Endocrinology, East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Tel/Fax [phone], Email [email protected]; [email protected]: The dusk phenomenon refers to a spontaneous and transient pre-dinner hyperglycemia that affects glucose fluctuation and glycemic control, and the increasing use of continuous glucose monitoring (CGM) has facilitated its diagnosis. We investigated the frequency of the dusk phenomenon and its relationship with the time in range (TIR) in patients with type 2 diabetes mellitus (T2DM).Patients and Methods: This study involved 102 patients with T2DM who underwent CGM for 14 days. CGM-derived metrics and clinical characteristics were evaluated. A consecutive dusk blood glucose difference (pre-dinner glucose minus 2-hour post-lunch glucose) of ≥ 0 or once-only dusk blood glucose difference of 10 and %TAR> 13.9) (P ≤ 0.05). Adjusted for confounding factors, the binary logistic regression analysis showed a negative association of CLDP with %TIR (odds ratio 70% (P < 0.05). The negative association between TIR and CLDP still remained after adjustment by the binary logistic regression analysis.Conclusion: The CLDP was frequently present in patients with T2DM. The TIR was significantly correlated with the CLDP and could serve as an independent negative predictor.Keywords: time in range, dusk phenomenon, type 2 diabetes, continuous glucose monitoring

Keywords

• time in range
• dusk phenomenon
• type 2 diabetes
• continuous glucose monitoring