Frontiers in Nuclear Medicine (Jul 2023)

Gallium-68 fibroblast activation protein inhibitor positron emission tomography in cardiovascular disease

  • Dineo Mpanya,
  • Mike Sathekge,
  • Mike Sathekge,
  • Eric Klug,
  • Eric Klug,
  • Jenna Damelin,
  • Stuart More,
  • Bawinile Hadebe,
  • Bawinile Hadebe,
  • Mariza Vorster,
  • Mariza Vorster,
  • Nqoba Tsabedze

DOI
https://doi.org/10.3389/fnume.2023.1224905
Journal volume & issue
Vol. 3

Abstract

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Gallium-68 fibroblast activation protein inhibitor [(68Ga)Ga-FAPI] is a new radiopharmaceutical positioning itself as the preferred agent in patients with malignant tumours, competing with 2-Deoxy-2-[18F]fluoro-d-glucose [2-(18F)FDG] using positron emission tomography (PET). While imaging oncology patients with [68Ga]Ga-FAPI PET, incidental uptake of [68Ga]Ga-FAPI has been detected in the myocardium. This review summarises original research studies associating the visualisation of FAPI-based tracers in the myocardium with underlying active cardiovascular disease.

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