Communications Biology (May 2022)

Cortical D1 and D2 dopamine receptor availability modulate methylphenidate-induced changes in brain activity and functional connectivity

  • Peter Manza,
  • Ehsan Shokri-Kojori,
  • Şükrü Barış Demiral,
  • Corinde E. Wiers,
  • Rui Zhang,
  • Natasha Giddens,
  • Katherine McPherson,
  • Erin Biesecker,
  • Evan Dennis,
  • Allison Johnson,
  • Dardo Tomasi,
  • Gene-Jack Wang,
  • Nora D. Volkow

DOI
https://doi.org/10.1038/s42003-022-03434-5
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 9

Abstract

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Joint PET and MRI analyses of cortical D1 and D2 dopamine receptors in healthy adults provide a framework for understanding how dopamine-boosting drugs alter brain function.