Evaluating the prediction power and accuracy of two smart response surface experimental designs after revisiting repaglinide floating tablets

Abstract

Abstract Background There is a soar in the figure of companies aiming to achieve efficiency in undergoing experimental processes. Therefore, instead of deploying one-factor-at-a-time, design of experiments is becoming rampantly utilized in order to reduce the resources outflow. There are a copious of different smart designs which could be employed as design of experiments tools. Central composite and d-optimal designs were investigated in this paper. The purpose of this investigation was to compare the two designs and identify the most accurate design at analyzing, interpreting and making predictions with regards to the data offered. The aforementioned purpose was achieved by applying both designs to a preexisting study which sought to prolong the gastrointestinal retention of repaglinide tablets through deploying a full factorial design. Further optimization was performed using Design-Expert software after inducing an outlier point. Results R-squared, adjusted R-squared, predicted R-squared and adequate precision were computed in addition to acquiring diagnostics figures such as predicted versus actual, residual versus run, Box–Cox, contour plot and 3D surface plots. Model equations were also produced for each design. Results showed that both designs were successful at modeling the data both scoring r-squared values > 0.7 and adequate precision > 4 implying high fitting, prediction power and ability to navigate the experimental space using a reduced number of experimental runs. The d-optimal design obtained the least relative error of only 3.81%. Conclusions In conclusion, the d-optimal design provides a great tool for reduction of experimental testing which in turn diminishes resources consumption. Therefore, this design is favored to be enforced in the pharmaceutical sector.

Keywords

• Repaglinide
• Floating
• Optimization
• d-optimal
• Central composite