Nonadherence to Antiepileptic Medications: Still a Major Issue to be Addressed in the Management of Epilepsy

Journal of Neurosciences in Rural Practice. 2019;10(01):106-112 DOI 10.4103/jnrp.jnrp_136_18

 

Journal Homepage

Journal Title: Journal of Neurosciences in Rural Practice

ISSN: 0976-3147 (Print); 0976-3155 (Online)

Publisher: Thieme Publishers

Society/Institution: Associacion Ayuda Enfermo Neuroquirurgico (Association for Helping Neurosurgical Sick People)

LCC Subject Category: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry

Country of publisher: India

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB

 

AUTHORS


Azra Zafar (Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

Rizwana Shahid (Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

Saima Nazish (Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

Danah Aljaafari (Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

Fahd Ali Alkhamis (Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

Sadiq Alsalman (Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

Amir H. Msmar (Department of Research Statistical Support, Deanship of Scientific Research, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

Badaruddin Abbasi (Department of Research Ethics, Deanship of Scientific Research, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

Abdulla A. Alsulaiman (Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

Majed Alabdali (Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia)

EDITORIAL INFORMATION

Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 22 weeks

 

Abstract | Full Text

Context: Medication nonadherence is a significant barrier in achieving seizure freedom in patients with epilepsy. There is a deficiency of data about the reasons for nonadherence in Saudi population. Aims: The aim of this study is to prove the existence of nonadherence to antiepileptic drugs (AEDs) in patients with epilepsy and identify the responsible factors. Setting and Design: This is a prospective, cross-sectional study carried in the Department of Neurology at King Fahd Hospital of the University affiliated with Imam Abdulrahman Bin Faisal University. Subjects and Methods: Patients of all ages diagnosed to have epilepsy as mentioned in their medical record and taking antiepileptic medications were interviewed using a questionnaire. Statistical Analysis Used: Statistical analysis was performed using IBM Statistical Package for the Social Sciences version 21 (IBM Corp., Armonk, NY, USA). Statistical significance was defined as two-tailed with a P ≤ 0.05. Results: Among 152 participants, 52.6% were male and 47.4% were female. Mean age of the patients was 28 ± 14.3 (mean ± standard deviation) years. Of 152 patients, 48.7% were found to be nonadherent to their AED therapy. The most commonly identified factor was forgetfulness. Nonadherence was significantly associated with poor seizure control (P = 0.002). Conclusion: Nonadherence to the AED is common among patients with epilepsy and affects seizure control adversely.