Morphofunctional markers of the efficiency stimulated by the pool proliferation of the nasal mucosa cells in patients with polyposis rinosinusitis

Abstract

Background. The article highlights potential pathomorphological and pathophysiological mechanisms of effective treatment of polypous rhinosinusitis. Materials and methods. The study included patients diagnosed with bilateral polyposis rhinosinusitis, who were conducted immunohistochemical analysis of TLR9 expression using monoclonal antibodies in biopsy postoperative material (twice: prior to treatment and 20 days after treatment), and cytological examination of nasal reprint smears stained by Romanovsky-Giemsa method (immersion microscopy 7×90). Results. The study detected individual features of the proliferative activity of the epithelial pool of the nasal mucosa and pathological polyposis tissue in response to complex immunocorrective therapy. Conclusions. The results obtained allow including immunocorrective therapy in the complex treatment of polyposis rhinosinusitis to reduce possible relapses of the pathology.

Keywords

• polyp
• tlr9 expression
• rhinosinusitis
• pathological markers