Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform

Abstract

Glycine-alanine dipeptide repeats produced by the C9orf72 gene are proposed to cause neurotoxicity in related diseases, but is challenging to study experimentally. Here a photolabile cell-penetrating peptide allows superresolution imaging of the distribution and aggregation of a simple dipeptide which recapitulates neurotoxicity associated with endogenous analogues.