Antioxidants (Dec 2022)
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort
- Mercedes Gil-Lespinard,
- Jazmín Castañeda,
- Enrique Almanza-Aguilera,
- Jesús Humberto Gómez,
- Anne Tjønneland,
- Cecilie Kyrø,
- Kim Overvad,
- Verena Katzke,
- Matthias B. Schulze,
- Giovanna Masala,
- Claudia Agnoli,
- Maria Santucci de Magistris,
- Rosario Tumino,
- Carlotta Sacerdote,
- Guri Skeie,
- Cristina Lasheras,
- Esther Molina-Montes,
- José María Huerta,
- Aurelio Barricarte,
- Pilar Amiano,
- Emily Sonestedt,
- Marisa da Silva,
- Ingegerd Johansson,
- Johan Hultdin,
- Anne M. May,
- Nita G. Forouhi,
- Alicia K. Heath,
- Heinz Freisling,
- Elisabete Weiderpass,
- Augustin Scalbert,
- Raul Zamora-Ros
Affiliations
- Mercedes Gil-Lespinard
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain
- Jazmín Castañeda
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain
- Enrique Almanza-Aguilera
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain
- Jesús Humberto Gómez
- Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, 30008 Murcia, Spain
- Anne Tjønneland
- Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark
- Cecilie Kyrø
- Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark
- Kim Overvad
- Department of Public Health, Aarhus University, DK-8000 Aarhus, Denmark
- Verena Katzke
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
- Matthias B. Schulze
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
- Giovanna Masala
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network—ISPRO, 50139 Florence, Italy
- Claudia Agnoli
- Epidemiology and Prevention Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian, 20133 Milan, Italy
- Maria Santucci de Magistris
- Department of Clinical and Experimental Medicine, Federico II University, 80131 Naples, Italy
- Rosario Tumino
- Hyblean Association for Epidemiological Research (AIRE-ONLUS), 97100 Ragusa, Italy
- Carlotta Sacerdote
- Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, 10124 Turin, Italy
- Guri Skeie
- Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway
- Cristina Lasheras
- Department of Functional Biology, University of Oviedo, 33007 Oviedo, Spain
- Esther Molina-Montes
- CIBER in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- José María Huerta
- Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, 30008 Murcia, Spain
- Aurelio Barricarte
- CIBER in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Pilar Amiano
- CIBER in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Emily Sonestedt
- Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, 22184 Malmö, Sweden
- Marisa da Silva
- Register-Based Epidemiology, Department of Clinical Sciences Lund, Lund University, 22184 Lund, Sweden
- Ingegerd Johansson
- Department of Odontology, Umeå University, 90187 Umeå, Sweden
- Johan Hultdin
- Department of Medical Biosciences, Umeå University, 90187 Umeå, Sweden
- Anne M. May
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands
- Nita G. Forouhi
- MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge Biomedical Campus, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SL, UK
- Alicia K. Heath
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK
- Heinz Freisling
- International Agency for Research on Cancer (IARC-WHO), 69008 Lyon, France
- Elisabete Weiderpass
- International Agency for Research on Cancer (IARC-WHO), 69008 Lyon, France
- Augustin Scalbert
- International Agency for Research on Cancer (IARC-WHO), 69008 Lyon, France
- Raul Zamora-Ros
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain
- DOI
- https://doi.org/10.3390/antiox11122425
- Journal volume & issue
-
Vol. 11,
no. 12
p. 2425
Abstract
Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: −0.071 (95% CI: −0.085; −0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.
Keywords