Nature Communications (Apr 2020)
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
- Fanlei Hu,
- Xiang Jiang,
- Chunqing Guo,
- Yingni Li,
- Shixian Chen,
- Wei Zhang,
- Yan Du,
- Ping Wang,
- Xi Zheng,
- Xiangyu Fang,
- Xin Li,
- Jing Song,
- Yang Xie,
- Fei Huang,
- Jimeng Xue,
- Mingxin Bai,
- Yuan Jia,
- Xu Liu,
- Limin Ren,
- Xiaoying Zhang,
- Jianping Guo,
- Hudan Pan,
- Yin Su,
- Huanfa Yi,
- Hua Ye,
- Daming Zuo,
- Juan Li,
- Huaxiang Wu,
- Yongfu Wang,
- Ru Li,
- Liang Liu,
- Xiang-Yang Wang,
- Zhanguo Li
Affiliations
- Fanlei Hu
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Xiang Jiang
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Chunqing Guo
- Department of Human & Molecular Genetics, Virginia Commonwealth University, School of Medicine
- Yingni Li
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Shixian Chen
- Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University
- Wei Zhang
- Department of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity
- Yan Du
- Department of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of Medicine
- Ping Wang
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Xi Zheng
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Xiangyu Fang
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Xin Li
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Jing Song
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Yang Xie
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Fei Huang
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Jimeng Xue
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Mingxin Bai
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Yuan Jia
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Xu Liu
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Limin Ren
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Xiaoying Zhang
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Jianping Guo
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Hudan Pan
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Yin Su
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Huanfa Yi
- Department of Human & Molecular Genetics, Virginia Commonwealth University, School of Medicine
- Hua Ye
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Daming Zuo
- Department of Human & Molecular Genetics, Virginia Commonwealth University, School of Medicine
- Juan Li
- Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University
- Huaxiang Wu
- Department of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of Medicine
- Yongfu Wang
- Department of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity
- Ru Li
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- Liang Liu
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Xiang-Yang Wang
- Department of Human & Molecular Genetics, Virginia Commonwealth University, School of Medicine
- Zhanguo Li
- Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
- DOI
- https://doi.org/10.1038/s41467-020-15700-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice.
