Известия высших учебных заведений. Поволжский регион: Медицинские науки (Jun 2022)
The effect of sympathetic nervous system stimulation on cardiac rhythm variability indices in laboratory conditions
Abstract
Background. This study presents new approaches to the mechanisms of regulation and mutual influences of the sympathetic division of the autonomic nervous system (ANS) and indicators of cardiac activity at different stages of the maturation of the nervous system. Materials and methods. The object of the study is white non-fertile rats aged one, three, six and twenty weeks in the amount of 38 individuals (wiring of the Department of Anatomy, Physiology and Human Health Protection of Kazan Federal (Volga) University). The Ca-blocker verapamil was injected into the right femoral at a dose of 0.1 mg/kg, nonselective α, β-adrenomimetic noradrenaline was administered at a dose of 0.01mg/kg. As part of the study, the indicators of the variation pulsogram were evaluated and processed on a personal computer. Results. In adult and 6-week-old animals, the introduction of the Cablocker verapamil together with the noradrenalin adrenomimetic eliminated its positive chronotropic effect. Administration of a similar combination of drugs in animals of 1 and 3 weeks of age led to an increase in rat heart chronotropy. Against the background of combined administration of noradrenalin adrenomimetic and Ca-blocker verapamil, statistically significant increases in heart rate were detected in rats at the age of three weeks, with twophase acceleration of HR observed. Conclusion. Against the background of the use of noradrenalin and blockade of calcium currents, depending on the various stages of ripening of nervous system, special chronotropic effects on the heart were found. In adults and six weeks of animals, the administration of the Ca-blocker verapamil together with the adrenomimetic noradrenalin eliminated its positive chronotropic effect.
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