BIOPHYSICAL BASES OF GENOME ORGANIZATION

Abstract

Aim - the analysis of nucleotide sequences of DNA molecules and the bases of the information storage with the help of DNA. Material and methods - the study is based on Markov chain theory and Bayesian Information Criterion. Results. Principles of genetic code construction were investigated. Specific nucleotide sequences were analyzed using Markov chain theory; the method of sequencing nucleotide sequences was described. Conclusion. A nucleotide sequence has certain restrictions associated with complementarity of the bases along DNA chain. These restrictions at the level of triplet sequence can be eliminated by degeneracy of the genetic code.

Keywords

• genome
• nucleotide sequence
• markov’s chains
• bayesian information criterion
• sequencing