Effect of obstructive sleep apnea syndrome on left ventricular function

Abstract

Background: The link between OSAS, left ventricular dysfunction, and congestive heart failure is less known, although OSAS is frequent in both systolic and diastolic heart failure patients. Aim: To study left ventricular function in patients with obstructive sleep apnea syndrome and to assess the correlation between the severity of OSA and the degree of ventricular dysfunction. Subjects and methods: This study was conducted on 45 subjects (22 males and 23 females) in Chest Department, Tanta University Hospitals, they were classified into two groups: Group A included 15 apparently healthy subjects, by sleep study they were normal as apnea hypopnea index (AHI) 5/h and ODI > 5/h). Results: Eight (26.66%) out of the 30 OSAS patients (group B) were hypertensive and have left ventricular dysfunction. The mean value of AHI was (2.53±1.06) and (24.6±14.35) in groups A and B, respectively. The mean value of AHI was significantly higher in group B than group A (p=0.001). Significant correlation was found between AHI, diastolic and systolic dysfunctions, respectively (r= 0.324; p= 0.019 and r=0.288; p=0.049). Conclusion: Obstructive sleep apnea syndrome may predispose in left ventricular diastolic dysfunction, AHI is correlated with the degree of left ventricular diastolic dysfunction.

Keywords

• OSA
• AHI
• ODI
• LVF