Nature Communications (Aug 2018)

Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence

  • G. Costa,
  • M. Gildenhard,
  • M. Eldering,
  • R. L. Lindquist,
  • A. E. Hauser,
  • R. Sauerwein,
  • C. Goosmann,
  • V. Brinkmann,
  • P. Carrillo-Bustamante,
  • E. A. Levashina

DOI
https://doi.org/10.1038/s41467-018-05893-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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The evolution of within-host malaria virulence has been studied, but the vector’s contribution isn’t well understood. Here, Costa et al. show that non-competitive parasitic resource exploitation within-vector, in particular lipid trafficking, restricts within-host infectivity and virulence of the parasite.