eJournal of Oral Maxillofacial Research (Dec 2018)

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

  • Ricardo Basto Souza,
  • Francisco Isaac Fernandes Gomes,
  • Karuza Maria Alves Pereira,
  • Paula Goes Pinheiro Dutra,
  • Rodrigo Maranguape Silva da Cunha,
  • Hellíada Vasconcelos Chaves,
  • Mirna Marques Bezerra

DOI
https://doi.org/10.5037/jomr.2018.9404
Journal volume & issue
Vol. 9, no. 4
p. e4

Abstract

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Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects. Material and Methods: Male Wistar rats underwent nylon ligature placement around maxillary molars and were treated (v.o.) with strontium ranelate (20 or 100 mg/kg) for 7 days. After that, rats were euthanized and histomorphometric/histopathological analyses and RT-PCR for HO-1 expression were performed. Results: Strontium ranelate (20 or 100 mg/kg) prevented bone resorption by 28% and 38%, respectively. Strontium ranelate treatment (100 mg/kg) up-regulated (P < 0.05) heme oxygenase-1 mRNA levels in the gingival tissues in comparison to control groups. Conclusions: Strontium ranelate prevented periodontal bone loss in experimental periodontitis in rats while heme oxygenase-1 mRNA levels increased after treatment.

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