Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation

Abstract

Extracellular vesicles are composed of fragments of exfoliated plasma membrane, organelles or nuclei and are released after cell activation, apoptosis or destruction. Platelet-derived extracellular vesicles are the most abundant type of extracellular vesicle in the blood of patients with traumatic brain injury. Accumulated laboratory and clinical evidence shows that platelet-derived extracellular vesicles play an important role in coagulopathy and inflammation after traumatic brain injury. This review discusses the recent progress of research on platelet-derived extracellular vesicles in coagulopathy and inflammation and the potential of platelet-derived extracellular vesicles as therapeutic targets for traumatic brain injury.

Keywords

• angiogenesis; clotting factors; coagulopathy; delivery; inflammation; platelet-derived extracellular vesicles; review; target; traumatic brain injury