Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer

Jieti Wang; Ruochen Li; Yifan Cao; Yun Gu; Hanji Fang; Yuchao Fei; Kunpeng Lv; Xudong He; Chao Lin; Hao Liu; Heng Zhang; He Li; Hongyong He; Jiejie Xu; Hua Huang

doi:10.1038/s41467-021-23356-w

Nature Communications (May 2021)

Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer

Jieti Wang,
Ruochen Li,
Yifan Cao,
Yun Gu,
Hanji Fang,
Yuchao Fei,
Kunpeng Lv,
Xudong He,
Chao Lin,
Hao Liu,
Heng Zhang,
He Li,
Hongyong He,
Jiejie Xu,
Hua Huang

Affiliations

Jieti Wang: Department of Gastric Surgery, Shanghai Cancer Center, Fudan University
Ruochen Li: Department of General Surgery, Zhongshan Hospital, Fudan University
Yifan Cao: Department of General Surgery, Zhongshan Hospital, Fudan University
Yun Gu: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Hanji Fang: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Yuchao Fei: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Kunpeng Lv: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Xudong He: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Chao Lin: Department of General Surgery, Zhongshan Hospital, Fudan University
Hao Liu: Department of General Surgery, Zhongshan Hospital, Fudan University
Heng Zhang: Department of General Surgery, Zhongshan Hospital, Fudan University
He Li: Department of General Surgery, Zhongshan Hospital, Fudan University
Hongyong He: Department of General Surgery, Zhongshan Hospital, Fudan University
Jiejie Xu: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Hua Huang: Department of Gastric Surgery, Shanghai Cancer Center, Fudan University

DOI: https://doi.org/10.1038/s41467-021-23356-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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The prognostic value of tumor infiltrating lymphocytes in gastric cancer remains controversial. Here the authors show a consistent association between higher density of intratumoral CXCR5+CD8+ T cells and longer overall survival in four different cohorts of patients with gastric cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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