Nature Communications (Feb 2020)

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

  • Yue Sheng,
  • Chunjie Yu,
  • Yin Liu,
  • Chao Hu,
  • Rui Ma,
  • Xinyan Lu,
  • Peng Ji,
  • Jianjun Chen,
  • Benjamin Mizukawa,
  • Yong Huang,
  • Jonathan D. Licht,
  • Zhijian Qian

DOI
https://doi.org/10.1038/s41467-020-14590-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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FOXM1 is a known transcription factor which promotes cell proliferation in cancer cells. Here, the authors show that FOXM1 is required for the maintenance of quiescence and self-renewal of leukemia stem cells in MLL-AF9-rearranged acute myeloid leukemia patient and mouse models.