Inflammatory status hepatic enzymes and serum creatinine in HIV-, HIV+ and HIV-TB co-infected adult Central Africans

Abstract

Etienne Mokondjimobe,1,2 Benjamin Longo-Mbenza,3 Patou Mampouya-Arrouse,1 Henri Joseph Parra,1,2 Martin Diatewa11Laboratory de Biochemistry-Pharmacology, Faculty of Health Sciences, 2National Laboratory of Public Health, Brazzaville, Congo; 3Faculty of Health Sciences, Walter Sisulu University, Mthatha, South AfricaBackground and aim: Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome is a major public health issue in Africa. The objective of this study was to determine which of isolated HIV-infection, isolated naive pulmonary tuberculosis (PTB), or naive HIV-PTB coinfection was more harmful to inflammatory, hepatic, and renal functions.Methods: This cross-sectional study was undertaken among ten patients with isolated HIV infection, ten patients with isolated naive HIV infection, ten patients with isolated PTB and 32 patients with HIV-PTB coinfection, with the aim of determining which group had the highest levels of oxidative stress and hepatic and renal dysfunction markers. Serum aminotransferase (AST), alanine transferase (ALT), gamma-glutamyl transferase (GGT), and creatinine measurements were compared across the three groups of patients, who were managed from admission in the pulmonology division of the Brazzaville Teaching Hospital, Congo.Results: HIV patients had the highest levels of ALT, GGT, and creatinine before and after adjusting for age and sex. Adjusted levels of AST, ALT, GGT, and creatinine were higher in HIV-PTB coinfection patients than in sero-negative PTB patients.Conclusion: There is a significant association between HIV infection and increase in concentration of ALT, GGT, and creatinine.Keywords: Africa, tuberculosis, HIV-tuberculosis coinfection, renal function