Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential

Larissa Lavorato Lima; Rebeca Mól Lima; Annelisa Farah da Silva; Antônio Márcio Resende do Carmo; Adilson David da Silva; Nádia Rezende Barbosa Raposo

doi:10.1155/2013/274643

The Scientific World Journal (Jan 2013)

Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential

Larissa Lavorato Lima,
Rebeca Mól Lima,
Annelisa Farah da Silva,
Antônio Márcio Resende do Carmo,
Adilson David da Silva,
Nádia Rezende Barbosa Raposo

Affiliations

Larissa Lavorato Lima: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil
Rebeca Mól Lima: Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil
Annelisa Farah da Silva: Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil
Antônio Márcio Resende do Carmo: Faculdade de Odontologia, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil
Adilson David da Silva: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil
Nádia Rezende Barbosa Raposo: Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil

DOI: https://doi.org/10.1155/2013/274643
Journal volume & issue: Vol. 2013

Abstract

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This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA50 = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P<0.001). The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring.

Published in The Scientific World Journal

ISSN: 2356-6140 (Print); 1537-744X (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Technology; Medicine; Science
Website: https://onlinelibrary.wiley.com/journal/8086

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