First report of occurrence of Mycobacterium tuberculosis and Non-tuberculous mycobacteria in a heterozygous carrier of chronic granulomatous patient

Abstract

Tuberculosis (TB) is one of the most common infections world-wide, and in 2012, an estimated 8.6 million people developed TB and 1.3 million died from the disease (including 320,000 deaths among HIV-positive people). Mycobacterium tuberculosis (MTB) is an intracellular pathogen capable of infecting and surviving within the hosts mononuclear cells, particularly macrophages. This involves sequestration of MTB within organized granulomas. Nontuberculous mycobacteria refers to all the species in the family of Mycobacteria that may cause human disease, but does not cause TB. Every year in the world approximately 2 people per 100,000 population develop infections caused by these lesser-known “cousins” of TB and leprosy. In this study, the focus is on a rare case of a patient with chronic granulomatous disease presenting with both MTB and Nontuberculous mycobacteria. As far as this research is concerned, this is the first report of a carrier patient with chronic granulomatous disease combined with MTB and Nontuberculous mycobacteria. The presented information may help to improve the diagnosis and open a new light in the investigation of susceptibility of patients to Mycobacterium infections.

Keywords

• MBT
• NTB