Effect of biannual azithromycin distribution on antibody responses to malaria, bacterial, and protozoan pathogens in Niger

Ahmed M. Arzika; Ramatou Maliki; E. Brook Goodhew; Eric Rogier; Jeffrey W. Priest; Elodie Lebas; Kieran S. O’Brien; Victoria Le; Catherine E. Oldenburg; Thuy Doan; Travis C. Porco; Jeremy D. Keenan; Thomas M. Lietman; Diana L. Martin; Benjamin F. Arnold; MORDOR-Niger Study Group

doi:10.1038/s41467-022-28565-5

Nature Communications (Feb 2022)

Effect of biannual azithromycin distribution on antibody responses to malaria, bacterial, and protozoan pathogens in Niger

Ahmed M. Arzika,
Ramatou Maliki,
E. Brook Goodhew,
Eric Rogier,
Jeffrey W. Priest,
Elodie Lebas,
Kieran S. O’Brien,
Victoria Le,
Catherine E. Oldenburg,
Thuy Doan,
Travis C. Porco,
Jeremy D. Keenan,
Thomas M. Lietman,
Diana L. Martin,
Benjamin F. Arnold,
MORDOR-Niger Study Group

Affiliations

Ahmed M. Arzika: The Carter Center
Ramatou Maliki: The Carter Center
E. Brook Goodhew: Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention
Eric Rogier: Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention
Jeffrey W. Priest: Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention
Elodie Lebas: Francis I. Proctor Foundation, University of California
Kieran S. O’Brien: Francis I. Proctor Foundation, University of California
Victoria Le: Francis I. Proctor Foundation, University of California
Catherine E. Oldenburg: Francis I. Proctor Foundation, University of California
Thuy Doan: Francis I. Proctor Foundation, University of California
Travis C. Porco: Francis I. Proctor Foundation, University of California
Jeremy D. Keenan: Francis I. Proctor Foundation, University of California
Thomas M. Lietman: Francis I. Proctor Foundation, University of California
Diana L. Martin: Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention
Benjamin F. Arnold: Francis I. Proctor Foundation, University of California
MORDOR-Niger Study Group

DOI: https://doi.org/10.1038/s41467-022-28565-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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In a randomized placebo-controlled trial in rural Niger, biannual azithromycin distribution to children 1-59 months reduced all-cause mortality. Based on serology, Arzika et al. here report a reduction of Campylobacter infection, supporting one mechanism for the intervention’s impact on mortality.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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