Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension

Mitsushige Murata; Takashi Kawakami; Masaharu Kataoka; Takashi Kohno; Yuji Itabashi; Keiichi Fukuda

doi:10.1177/2045893217746111

Pulmonary Circulation (Dec 2017)

Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension

Mitsushige Murata,
Takashi Kawakami,
Masaharu Kataoka,
Takashi Kohno,
Yuji Itabashi,
Keiichi Fukuda

Affiliations

Mitsushige Murata: Department of Laboratory Medicine, School of Medicine, Keio University, Tokyo, Japan
Takashi Kawakami: Department of Cardiology, School of Medicine, Keio University, Tokyo, Japan
Masaharu Kataoka: Department of Cardiology, School of Medicine, Keio University, Tokyo, Japan
Takashi Kohno: Department of Cardiology, School of Medicine, Keio University, Tokyo, Japan
Yuji Itabashi: Department of Cardiology, School of Medicine, Keio University, Tokyo, Japan
Keiichi Fukuda: Department of Cardiology, School of Medicine, Keio University, Tokyo, Japan

DOI: https://doi.org/10.1177/2045893217746111
Journal volume & issue: Vol. 8

Abstract

Read online

Riociguat is a soluble guanylate cyclase stimulator used for pulmonary hypertension (PH) treatment. We evaluated right ventricular (RV) contractile function in 27 PH patients receiving riociguat. A comparison of pre- and post-administration echocardiographic studies demonstrated significantly improved RV strain after riociguat treatment, even after adjusting for RV afterload.

Published in Pulmonary Circulation

ISSN: 2045-8940 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system; Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: https://onlinelibrary.wiley.com/journal/20458940

About the journal