Royal Society Open Science (Apr 2022)

Catalyst-free decarboxylation of 4-hydroxycinnamic acids: efficient synthesis of 4-vinylphenols

  • Qian Yang,
  • Youjuan Li,
  • Huanhuan Liu,
  • Enhua Wang,
  • Mei Peng,
  • Tingfei Deng,
  • Xiong Pan,
  • Zhongsheng Luo,
  • Yanfang Yan,
  • Lishou Yang,
  • Xiaosheng Yang

DOI
https://doi.org/10.1098/rsos.220014
Journal volume & issue
Vol. 9, no. 4

Abstract

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We report herein an efficient protocol for the synthesis of 4-vinylphenols by a catalyst-free decarboxylation of trans-4-hydroxycinnamic acids. A variety of 4-vinylphenols has been synthesized in moderate to excellent yields. This protocol also features no polymerization.

Keywords