Nature Communications (Mar 2020)

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin

  • Sindhuja Gowrisankaran,
  • Sébastien Houy,
  • Johanna G. Peña del Castillo,
  • Vicky Steubler,
  • Monika Gelker,
  • Jana Kroll,
  • Paulo S. Pinheiro,
  • Dirk Schwitters,
  • Nils Halbsgut,
  • Arndt Pechstein,
  • Jan R. T. van Weering,
  • Tanja Maritzen,
  • Volker Haucke,
  • Nuno Raimundo,
  • Jakob B. Sørensen,
  • Ira Milosevic

DOI
https://doi.org/10.1038/s41467-020-14993-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Endophilins-A are conserved membrane-associated proteins required for endocytosis. Here, the authors report that endophilins-A also promote exocytosis of neurosecretory vesicles by coordinating priming and fusion through intersectin-1, independently of their roles in different types of endocytosis.