Nature Communications (Mar 2020)
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin
- Sindhuja Gowrisankaran,
- Sébastien Houy,
- Johanna G. Peña del Castillo,
- Vicky Steubler,
- Monika Gelker,
- Jana Kroll,
- Paulo S. Pinheiro,
- Dirk Schwitters,
- Nils Halbsgut,
- Arndt Pechstein,
- Jan R. T. van Weering,
- Tanja Maritzen,
- Volker Haucke,
- Nuno Raimundo,
- Jakob B. Sørensen,
- Ira Milosevic
Affiliations
- Sindhuja Gowrisankaran
- European Neuroscience Institute—A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society Göttingen
- Sébastien Houy
- University of Copenhagen, Department for Neuroscience, Faculty of Health and Medical Sciences
- Johanna G. Peña del Castillo
- European Neuroscience Institute—A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society Göttingen
- Vicky Steubler
- European Neuroscience Institute—A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society Göttingen
- Monika Gelker
- European Neuroscience Institute—A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society Göttingen
- Jana Kroll
- European Neuroscience Institute—A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society Göttingen
- Paulo S. Pinheiro
- University of Copenhagen, Department for Neuroscience, Faculty of Health and Medical Sciences
- Dirk Schwitters
- European Neuroscience Institute—A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society Göttingen
- Nils Halbsgut
- European Neuroscience Institute—A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society Göttingen
- Arndt Pechstein
- Leibniz Research Institute for Molecular Pharmacology, Molecular Physiology and Cell Biology Section
- Jan R. T. van Weering
- Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam UMC
- Tanja Maritzen
- Leibniz Research Institute for Molecular Pharmacology, Molecular Physiology and Cell Biology Section
- Volker Haucke
- Leibniz Research Institute for Molecular Pharmacology, Molecular Physiology and Cell Biology Section
- Nuno Raimundo
- Institute for Cellular Biochemistry, University Medical Center Göttingen (UMG)
- Jakob B. Sørensen
- University of Copenhagen, Department for Neuroscience, Faculty of Health and Medical Sciences
- Ira Milosevic
- European Neuroscience Institute—A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society Göttingen
- DOI
- https://doi.org/10.1038/s41467-020-14993-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Endophilins-A are conserved membrane-associated proteins required for endocytosis. Here, the authors report that endophilins-A also promote exocytosis of neurosecretory vesicles by coordinating priming and fusion through intersectin-1, independently of their roles in different types of endocytosis.
