DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis

Nicole Y. Souren; Lisa A. Gerdes; Pavlo Lutsik; Gilles Gasparoni; Eduardo Beltrán; Abdulrahman Salhab; Tania Kümpfel; Dieter Weichenhan; Christoph Plass; Reinhard Hohlfeld; Jörn Walter

doi:10.1038/s41467-019-09984-3

Nature Communications (May 2019)

DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis

Nicole Y. Souren,
Lisa A. Gerdes,
Pavlo Lutsik,
Gilles Gasparoni,
Eduardo Beltrán,
Abdulrahman Salhab,
Tania Kümpfel,
Dieter Weichenhan,
Christoph Plass,
Reinhard Hohlfeld,
Jörn Walter

Affiliations

Nicole Y. Souren: Department of Genetics/Epigenetics, Saarland University
Lisa A. Gerdes: Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
Pavlo Lutsik: Division of Cancer Epigenomics, German Cancer Research Center (DKFZ)
Gilles Gasparoni: Department of Genetics/Epigenetics, Saarland University
Eduardo Beltrán: Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
Abdulrahman Salhab: Department of Genetics/Epigenetics, Saarland University
Tania Kümpfel: Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
Dieter Weichenhan: Division of Cancer Epigenomics, German Cancer Research Center (DKFZ)
Christoph Plass: Division of Cancer Epigenomics, German Cancer Research Center (DKFZ)
Reinhard Hohlfeld: Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
Jörn Walter: Department of Genetics/Epigenetics, Saarland University

DOI: https://doi.org/10.1038/s41467-019-09984-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Monozygotic (MZ) twins are ideal to study the influence of non-genetic factors on complex phenotypes. Here, Souren et al. perform an EWAS in peripheral blood mononuclear cells from 45 MZ twins discordant for multiple sclerosis and identify disease and treatment-associated epigenetic markers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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