Nature Communications (Oct 2022)
Structure of the core human NADPH oxidase NOX2
- Sigrid Noreng,
- Naruhisa Ota,
- Yonglian Sun,
- Hoangdung Ho,
- Matthew Johnson,
- Christopher P. Arthur,
- Kellen Schneider,
- Isabelle Lehoux,
- Christopher W. Davies,
- Kyle Mortara,
- Kit Wong,
- Dhaya Seshasayee,
- Matthieu Masureel,
- Jian Payandeh,
- Tangsheng Yi,
- James T. Koerber
Affiliations
- Sigrid Noreng
- Department of Structural Biology, Genentech Inc.
- Naruhisa Ota
- Department of Immunology, Genentech Inc.
- Yonglian Sun
- Department of Antibody Engineering, Genentech Inc.
- Hoangdung Ho
- Department of Structural Biology, Genentech Inc.
- Matthew Johnson
- Department of Structural Biology, Genentech Inc.
- Christopher P. Arthur
- Department of Structural Biology, Genentech Inc.
- Kellen Schneider
- Department of Antibody Engineering, Genentech Inc.
- Isabelle Lehoux
- Department of Biomolecular Resources, Genentech Inc.
- Christopher W. Davies
- Department of Antibody Engineering, Genentech Inc.
- Kyle Mortara
- Department of Biomolecular Resources, Genentech Inc.
- Kit Wong
- DevSci OMNI-Biomarker Development, Genentech Inc.
- Dhaya Seshasayee
- Department of Antibody Engineering, Genentech Inc.
- Matthieu Masureel
- Department of Structural Biology, Genentech Inc.
- Jian Payandeh
- Department of Structural Biology, Genentech Inc.
- Tangsheng Yi
- Department of Immunology, Genentech Inc.
- James T. Koerber
- Department of Antibody Engineering, Genentech Inc.
- DOI
- https://doi.org/10.1038/s41467-022-33711-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
NADPH oxidase NOX2 produces superoxide, a reactive oxygen species essential in innate immunity. Here, the authors reveal the structure of the NOX2 core, rationalize disease-causing mutations, and suggest avenues for selective NOX2 pharmacological modulation.
