Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes

Seiichi Yano; Takashi Ishiuchi; Shusaku Abe; Satoshi H. Namekawa; Gang Huang; Yoshihiro Ogawa; Hiroyuki Sasaki

doi:10.1038/s41467-022-32141-2

Nature Communications (Aug 2022)

Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes

Seiichi Yano,
Takashi Ishiuchi,
Shusaku Abe,
Satoshi H. Namekawa,
Gang Huang,
Yoshihiro Ogawa,
Hiroyuki Sasaki

Affiliations

Seiichi Yano: Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University
Takashi Ishiuchi: Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University
Shusaku Abe: Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University
Satoshi H. Namekawa: Department of Microbiology & Molecular Genetics, University of California Davis
Gang Huang: Department of Cell Systems & Anatomy and Department of Pathology & Laboratory Medicine, UT Health San Antonio, Joe R. and Teresa Lozano Long School of Medicine
Yoshihiro Ogawa: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Hiroyuki Sasaki: Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University

DOI: https://doi.org/10.1038/s41467-022-32141-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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DNMT3A is known to methylate DNA at histone H3 lysine 36 (H3K36me3)-marked transcriptionally active regions in mouse oocytes. Here the authors show that DNMT3A is also guided by H3K36me2 to methylate broad domains in genic and intergenic loci, as well as on the X chromosome. These two histone marks together comprise the minimal chromatin signature for global DNA methylation in mouse oocytes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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