Frontiers in Medicine (Mar 2022)

Patients With Suspected Severe Adverse Reactions to COVID-19 Vaccination Admitted to Intensive Care Unit: A Case Report

  • Denise Battaglini,
  • Denise Battaglini,
  • Lorenzo Ball,
  • Lorenzo Ball,
  • Chiara Robba,
  • Chiara Robba,
  • Simona Maiani,
  • Iole Brunetti,
  • Luana Benedetti,
  • Luana Benedetti,
  • Lucio Castellan,
  • Gianluigi Zona,
  • Gianluigi Zona,
  • Giampaola Pesce,
  • Giampaola Pesce,
  • Patricia R. M. Rocco,
  • Paolo Pelosi,
  • Paolo Pelosi

DOI
https://doi.org/10.3389/fmed.2022.823837
Journal volume & issue
Vol. 9

Abstract

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BackgroundSeveral cases of adverse reactions following vaccination for coronavirus disease 2019 (COVID-19) with adenoviral vector vaccines or mRNA-based vaccines have been reported to date. The underlying syndrome has been named “vaccine-induced immune thrombotic thrombocytopenia” (VITT) or “thrombosis with thrombocytopenia syndrome (TTS)” with different clinical manifestations.MethodsWe report the clinical course of five patients who had severe adverse reactions to COVID-19 vaccines, either with VITT/TTS, abdominal or pulmonary thrombosis after adenoviral vaccines, or Stevens' Johnson syndrome because of mRNA vaccination, all of whom required admission to the intensive care unit (ICU).ConclusionsAll patients with severe or life-threatening suspected reaction to different types of COVID-19 vaccination required ICU admission. A prompt evaluation of early symptoms and individualized clinical management is needed to improve outcomes.

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