Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Catarina F. Almeida; Srinivasan Sundararaj; Jérôme Le Nours; T. Praveena; Benjamin Cao; Satvika Burugupalli; Dylan G. M. Smith; Onisha Patel; Manfred Brigl; Daniel G. Pellicci; Spencer J. Williams; Adam P. Uldrich; Dale I. Godfrey; Jamie Rossjohn

doi:10.1038/s41467-019-12941-9

Nature Communications (Nov 2019)

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Catarina F. Almeida,
Srinivasan Sundararaj,
Jérôme Le Nours,
T. Praveena,
Benjamin Cao,
Satvika Burugupalli,
Dylan G. M. Smith,
Onisha Patel,
Manfred Brigl,
Daniel G. Pellicci,
Spencer J. Williams,
Adam P. Uldrich,
Dale I. Godfrey,
Jamie Rossjohn

Affiliations

Catarina F. Almeida: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Srinivasan Sundararaj: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Jérôme Le Nours: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
T. Praveena: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Benjamin Cao: School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Satvika Burugupalli: School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Dylan G. M. Smith: School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Onisha Patel: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Manfred Brigl: Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School
Daniel G. Pellicci: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Spencer J. Williams: Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne
Adam P. Uldrich: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Dale I. Godfrey: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Jamie Rossjohn: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University

DOI: https://doi.org/10.1038/s41467-019-12941-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose that type II NKT TCRs may adapt multiple CD1d docking modes to maximise antigen recognition efficacy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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