Indian Heart Journal (Nov 2017)

Atrial electrical abnormality in patients with Brugada syndrome assessed by signal-averaged electrocardiography

  • Yasutsugu Nagamoto,
  • Yuto Fujii,
  • Yuichi Morita,
  • Yusuke Ueda,
  • Yasuko Miyake,
  • Kenichi Yamane,
  • Mai Fujiwara,
  • Shinji Mito,
  • Yuichiro Watari,
  • Hiromichi Tamekiyo,
  • Tomokazu Okimoto,
  • Yuji Muraoka,
  • Yasuhiko Hayashi

DOI
https://doi.org/10.1016/j.ihj.2017.05.008
Journal volume & issue
Vol. 69, no. 6
pp. 714 – 719

Abstract

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Background: Ventricular fibrillation and atrial fibrillation are well-known arrhythmias in patients with Brugada syndrome. This study evaluated the characteristics of the atrial arrhythmogenic substrate using the signal-averaged electrogram (SAECG) in patients with Brugada syndrome. Methods: SAECGs were performed during normal sinus rhythm in 23 normal volunteers (control group), 21 patients with paroxysmal atrial fibrillation (PAF; PAF group), and 21 with Brugada syndrome (Brugada group). Results: The filtered P wave duration (fPd) in the control, Brugada, and PAF groups was 113.9 ± 12.9 ms, 125.3 ± 15.0 ms, and 137.1 ± 16.3 ms, respectively. The fPd in the PAF group was significantly longer compared to that in the control and Brugada groups (p < 0.05). The fPd in the Brugada group was significantly longer than that in the control group (p < 0.05) and significantly shorter than that in the PAF group (p < 0.05). Conclusion: Patients with Brugada syndrome had abnormal P waves on the SAECG. The abnormal P waves on the SAECG in Brugada syndrome patients may have intermediate characteristics between control and PAF patients.

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