Nature Communications (Feb 2021)

Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis

  • Matthew F. Wipperman,
  • Shakti K. Bhattarai,
  • Charles Kyriakos Vorkas,
  • Venkata Suhas Maringati,
  • Ying Taur,
  • Laurent Mathurin,
  • Katherine McAulay,
  • Stalz Charles Vilbrun,
  • Daphie Francois,
  • James Bean,
  • Kathleen F. Walsh,
  • Carl Nathan,
  • Daniel W. Fitzgerald,
  • Michael S. Glickman,
  • Vanni Bucci

DOI
https://doi.org/10.1038/s41467-021-21475-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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Antibiotic therapy can lead to pathogen clearance, but also to alterations in the gut microbiota and systemic immune responses. Here, the authors analyze data from patients with tuberculosis and healthy subjects to show that pathogen clearance and gut microbiota alterations are independently associated with antibiotic-induced changes of the inflammatory response of active tuberculosis.