Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations

Silvia Mezi; Giulia Pomati; Andrea Botticelli; Francesca De Felice; Daniela Musio; Marco della Monaca; Sasan Amirhassankhani; Francesco Vullo; Bruna Cerbelli; Raffaella Carletti; Cira Di Gioia; Carlo Catalano; Valentino Valentini; Vincenzo Tombolini; Carlo Della Rocca; Paolo Marchetti

doi:10.1177/2036361320973526

Rare Tumors (Nov 2020)

Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations

Silvia Mezi,
Giulia Pomati,
Andrea Botticelli,
Francesca De Felice,
Daniela Musio,
Marco della Monaca,
Sasan Amirhassankhani,
Francesco Vullo,
Bruna Cerbelli,
Raffaella Carletti,
Cira Di Gioia,
Carlo Catalano,
Valentino Valentini,
Vincenzo Tombolini,
Carlo Della Rocca,
Paolo Marchetti

Affiliations

Silvia Mezi: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Giulia Pomati: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Andrea Botticelli: Department of Clinical and Molecular Medicine, “Sapienza” University of Rome, Rome, Italy
Francesca De Felice: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Daniela Musio: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Marco della Monaca: Department of Odontostomatological and Maxillo-Facial Science “Sapienza” University of Rome, Rome, Italy
Sasan Amirhassankhani: MSc Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Francesco Vullo: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Bruna Cerbelli: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Raffaella Carletti: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Cira Di Gioia: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Carlo Catalano: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Valentino Valentini: Department of Odontostomatological and Maxillo-Facial Science “Sapienza” University of Rome, Rome, Italy
Vincenzo Tombolini: Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy
Carlo Della Rocca: Department of Medical-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Latina, Italy
Paolo Marchetti: Department of Clinical and Molecular Medicine, “Sapienza” University of Rome, Rome, Italy

DOI: https://doi.org/10.1177/2036361320973526
Journal volume & issue: Vol. 12

Abstract

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Primary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was conducted, along with analysis of the association between treatment, clinical/pathological characteristics, and outcomes. Most patients (8) were staged IVa, with the majority of them (10) having G3 fast growing cancer. Local and systemic recurrence were reported in only three out of nine parotid cases (0 out of 2 submandibular SCGs). In two out of eight patients local relapse occurred after integrated treatment, while recurrence occurred in two out of three patients undergoing exclusive surgery. Five patients eventually died. Treatment of resectable disease must be aggressive and multimodal, with achievement of loco-regional control in order to reduce rate of recurrence and improve outcomes. Metastatic disease would require a therapeutic strategy tailored to the molecular profile in order to improve the currently disappointing results.

Published in Rare Tumors

ISSN: 2036-3605 (Print); 2036-3613 (Online)
Publisher: SAGE Publishing
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://journals.sagepub.com/home/rtu

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