Structural and functional changes of the cerebellum in temporal lobe epilepsy

Ge Wang; Ge Wang; Ge Wang; Xianghe Liu; Xianghe Liu; Xianghe Liu; Min Zhang; Min Zhang; Min Zhang; Kangrun Wang; Kangrun Wang; Kangrun Wang; Chaorong Liu; Chaorong Liu; Chaorong Liu; Yayu Chen; Yayu Chen; Yayu Chen; Wenyue Wu; Wenyue Wu; Haiting Zhao; Haiting Zhao; Haiting Zhao; Bo Xiao; Bo Xiao; Bo Xiao; Lily Wan; Lili Long; Lili Long; Lili Long

doi:10.3389/fneur.2023.1213224

Frontiers in Neurology (Aug 2023)

Structural and functional changes of the cerebellum in temporal lobe epilepsy

Ge Wang,
Ge Wang,
Ge Wang,
Xianghe Liu,
Xianghe Liu,
Xianghe Liu,
Min Zhang,
Min Zhang,
Min Zhang,
Kangrun Wang,
Kangrun Wang,
Kangrun Wang,
Chaorong Liu,
Chaorong Liu,
Chaorong Liu,
Yayu Chen,
Yayu Chen,
Yayu Chen,
Wenyue Wu,
Wenyue Wu,
Haiting Zhao,
Haiting Zhao,
Haiting Zhao,
Bo Xiao,
Bo Xiao,
Bo Xiao,
Lily Wan,
Lili Long,
Lili Long,
Lili Long

Affiliations

Ge Wang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Ge Wang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Ge Wang: Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Xianghe Liu: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Xianghe Liu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Xianghe Liu: Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Min Zhang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Min Zhang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Min Zhang: Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Kangrun Wang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Kangrun Wang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Kangrun Wang: Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Chaorong Liu: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Chaorong Liu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Chaorong Liu: Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Yayu Chen: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Yayu Chen: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Yayu Chen: Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China
Wenyue Wu: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Wenyue Wu: Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Haiting Zhao: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Haiting Zhao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Haiting Zhao: Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Bo Xiao: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Bo Xiao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Bo Xiao: Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Lily Wan: Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
Lili Long: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Lili Long: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Lili Long: Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fneur.2023.1213224
Journal volume & issue: Vol. 14

Abstract

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AimsThis study aimed to comprehensively explore the cerebellar structural and functional changes in temporal lobe epilepsy (TLE) and its association with clinical information.MethodsThe SUIT toolbox was utilized to perform cerebellar volume and diffusion analysis. In addition, we extracted the average diffusion values of cerebellar peduncle tracts to investigate microstructure alterations. Seed-based whole-brain analysis was used to investigate cerebellar–cerebral functional connectivity (FC). Subgroup analyses were performed to identify the cerebellar participation in TLE with/without hippocampal sclerosis (HS)/focal-to-bilateral tonic–clonic seizure (FBTCS) and TLE with different lateralization.ResultsTLE showed widespread gray matter atrophy in bilateral crusII, VIIb, VIIIb, left crusI, and left VIIIa. Both voxel and tract analysis observed diffusion abnormalities in cerebellar afferent peduncles. Reduced FC between the right crus II and the left parahippocampal cortex was found in TLE. Additionally, TLE showed increased FCs between left lobules VI–VIII and cortical nodes of the dorsal attention and visual networks. Across all patients, decreased FC was associated with poorer cognitive function, while increased FCs appeared to reflect compensatory effects. The cerebellar structural changes were mainly observed in HS and FBTCS subgroups and were regardless of seizure lateralization, while cerebellar–cerebral FC alterations were similar in all subgroups.ConclusionTLE exhibited microstructural changes in the cerebellum, mainly related to HS and FBTCS. In addition, altered cerebellar–cerebral functional connectivity is associated with common cognitive alterations in TLE.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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