The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral fat endoplasmic reticulum stress-induced inflammation

Guifen Qiang; Hyerim Whang Kong; Difeng Fang; Maximilian McCann; Xiuying Yang; Guanhua Du; Matthias Blüher; Jinfang Zhu; Chong Wee Liew

doi:10.1038/ncomms11378

Nature Communications (Apr 2016)

The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral fat endoplasmic reticulum stress-induced inflammation

Guifen Qiang,
Hyerim Whang Kong,
Difeng Fang,
Maximilian McCann,
Xiuying Yang,
Guanhua Du,
Matthias Blüher,
Jinfang Zhu,
Chong Wee Liew

Affiliations

Guifen Qiang: Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago
Hyerim Whang Kong: Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago
Difeng Fang: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases
Maximilian McCann: Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago
Xiuying Yang: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Guanhua Du: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Matthias Blüher: Department of Medicine, University of Leipzig
Jinfang Zhu: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases
Chong Wee Liew: Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago

DOI: https://doi.org/10.1038/ncomms11378
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Visceral and subcutaneous fat are associated with different metabolic risk, but mediators of such depot specific effects are not very well known. Here the authors identify the transcriptional regulator, TRIP-Br2, as a regulator of endoplasmic reticulum (ER) stress-induced inflammatory responses specifically in visceral fat.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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