Characterization of histone acylations links chromatin modifications with metabolism

Johayra Simithy; Simone Sidoli; Zuo-Fei Yuan; Mariel Coradin; Natarajan V. Bhanu; Dylan M. Marchione; Brianna J. Klein; Gleb A. Bazilevsky; Cheryl E. McCullough; Robert S. Magin; Tatiana G. Kutateladze; Nathaniel W. Snyder; Ronen Marmorstein; Benjamin A. Garcia

doi:10.1038/s41467-017-01384-9

Nature Communications (Oct 2017)

Characterization of histone acylations links chromatin modifications with metabolism

Johayra Simithy,
Simone Sidoli,
Zuo-Fei Yuan,
Mariel Coradin,
Natarajan V. Bhanu,
Dylan M. Marchione,
Brianna J. Klein,
Gleb A. Bazilevsky,
Cheryl E. McCullough,
Robert S. Magin,
Tatiana G. Kutateladze,
Nathaniel W. Snyder,
Ronen Marmorstein,
Benjamin A. Garcia

Affiliations

Johayra Simithy: Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania
Simone Sidoli: Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania
Zuo-Fei Yuan: Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania
Mariel Coradin: Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania
Natarajan V. Bhanu: Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania
Dylan M. Marchione: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Brianna J. Klein: Department of Pharmacology, University of Colorado School of Medicine
Gleb A. Bazilevsky: Graduate Group in Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania
Cheryl E. McCullough: Department of Chemistry, University of Pennsylvania
Robert S. Magin: Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania
Tatiana G. Kutateladze: Department of Pharmacology, University of Colorado School of Medicine
Nathaniel W. Snyder: AJ Drexel Autism Institute, Drexel University
Ronen Marmorstein: Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, and the Department of Chemistry, University of Pennsylvania
Benjamin A. Garcia: Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-017-01384-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

A number of histone lysine modifications related to acetylation have been identified, but their functional significance is unclear. Here, the authors use in vitro and in vivo assays to characterize eight acyl histone post-translational modifications and link their abundance with metabolism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal