Nature Communications (Feb 2023)

The ubiquitination landscape of the influenza A virus polymerase

  • Franziska Günl,
  • Tim Krischuns,
  • Julian A. Schreiber,
  • Lea Henschel,
  • Marius Wahrenburg,
  • Hannes C. A. Drexler,
  • Sebastian A. Leidel,
  • Vlad Cojocaru,
  • Guiscard Seebohm,
  • Alexander Mellmann,
  • Martin Schwemmle,
  • Stephan Ludwig,
  • Linda Brunotte

DOI
https://doi.org/10.1038/s41467-023-36389-0
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 19

Abstract

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Influenza A virus replication relies on host cell-derived ubiquitination of the viral polymerase. Here, Günl et al. show that site-specific ubiquitination of PB1-K578 is acquired during infection and facilitates spatiotemporal control of polymerase dimerization and NP binding.