Frontiers in Public Health (May 2022)
Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand
- Waritta Kunprom,
- Waritta Kunprom,
- Waritta Kunprom,
- Chaiwat Aphivatanasiri,
- Chaiwat Aphivatanasiri,
- Chaiwat Aphivatanasiri,
- Prakasit Sa-ngiamwibool,
- Prakasit Sa-ngiamwibool,
- Prakasit Sa-ngiamwibool,
- Sakkarn Sangkhamanon,
- Sakkarn Sangkhamanon,
- Sakkarn Sangkhamanon,
- Piyapharom Intarawichian,
- Piyapharom Intarawichian,
- Piyapharom Intarawichian,
- Walailak Bamrungkit,
- Walailak Bamrungkit,
- Walailak Bamrungkit,
- Malinee Thanee,
- Malinee Thanee,
- Malinee Thanee,
- Piya Prajumwongs,
- Piya Prajumwongs,
- Piya Prajumwongs,
- Watcharin Loilome,
- Watcharin Loilome,
- Watcharin Loilome,
- Narong Khuntikeo,
- Narong Khuntikeo,
- Narong Khuntikeo,
- Attapol Titapun,
- Attapol Titapun,
- Attapol Titapun,
- Apiwat Jareanrat,
- Apiwat Jareanrat,
- Apiwat Jareanrat,
- Vasin Thanasukarn,
- Vasin Thanasukarn,
- Vasin Thanasukarn,
- Tharatip Srisuk,
- Tharatip Srisuk,
- Tharatip Srisuk,
- Vor Luvira,
- Vor Luvira,
- Vor Luvira,
- Kulyada Eurboonyanun,
- Kulyada Eurboonyanun,
- Kulyada Eurboonyanun,
- Julaluck Promsorn,
- Julaluck Promsorn,
- Julaluck Promsorn,
- Supinda Koonmee,
- Supinda Koonmee,
- Supinda Koonmee
Affiliations
- Waritta Kunprom
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Waritta Kunprom
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Waritta Kunprom
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Chaiwat Aphivatanasiri
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Chaiwat Aphivatanasiri
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Chaiwat Aphivatanasiri
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Prakasit Sa-ngiamwibool
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Prakasit Sa-ngiamwibool
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Prakasit Sa-ngiamwibool
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Sakkarn Sangkhamanon
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Sakkarn Sangkhamanon
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Sakkarn Sangkhamanon
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Piyapharom Intarawichian
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Piyapharom Intarawichian
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Piyapharom Intarawichian
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Walailak Bamrungkit
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Walailak Bamrungkit
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Walailak Bamrungkit
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Malinee Thanee
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Malinee Thanee
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Malinee Thanee
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Piya Prajumwongs
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Piya Prajumwongs
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Piya Prajumwongs
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Watcharin Loilome
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Watcharin Loilome
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Watcharin Loilome
- Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Narong Khuntikeo
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Narong Khuntikeo
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Narong Khuntikeo
- Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Attapol Titapun
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Attapol Titapun
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Attapol Titapun
- Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Apiwat Jareanrat
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Apiwat Jareanrat
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Apiwat Jareanrat
- Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Vasin Thanasukarn
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Vasin Thanasukarn
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Vasin Thanasukarn
- Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Tharatip Srisuk
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Tharatip Srisuk
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Tharatip Srisuk
- Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Vor Luvira
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Vor Luvira
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Vor Luvira
- Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Kulyada Eurboonyanun
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Kulyada Eurboonyanun
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Kulyada Eurboonyanun
- Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Julaluck Promsorn
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Julaluck Promsorn
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Julaluck Promsorn
- Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Supinda Koonmee
- Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand
- Supinda Koonmee
- Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
- Supinda Koonmee
- Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- DOI
- https://doi.org/10.3389/fpubh.2022.816028
- Journal volume & issue
-
Vol. 10
Abstract
Distal cholangiocarcinoma (dCCA) is a rare type of CCA in Asia, even in Opisthorchis viverrini-prevalent Northeastern Thailand. The clinical ambiguity and imprecision of diagnosis surrounding this malignancy result in high mortality due often to advanced/metastatic disease on presentation. We aim to identify a prognostic factor that can improve the performance stratification and influence the outcome of dCCA patients after curative resection. A total of 79 patients who underwent curative-intended surgery for dCCA was enrolled. Possible risk factors for survival were analyzed with log-rank test, and independent factors with Cox regression model. dCCA patients were staged and classified according to the 8th edition the American Joint Committee on Cancer (AJCC) Staging Manual. Results were then compared with the revised classification employing the prognostic factor identified from multivariate analysis. Multivariate analysis revealed that growth pattern (p < 0.01) and distant metastasis (p = 0.012) were independent factors. Growth patterns comprise intraductal (ID), periductal infiltrating (PI), mass-forming (MF), and mixed types. When dCCA patients were grouped into those having good and poor outcomes (with and without ID components, respectively). The survival outcomes significantly differed among patients with and without ID components, which was better than with the 8th AJCC staging system in our cohort. Furthermore, Chi-square test showed that patterns without ID components (PI, MF, PI + MF) correlated with lymph node and distant metastasis. Therefore, classification of dCCA patients after curative-intended surgical resection based on growth pattern provides additional beneficial information for the prediction of survival in dCCA patients.
Keywords