Reducing MSH4 copy number prevents meiotic crossovers between non-homologous chromosomes in Brassica napus

Abstract

Non-homologous crossovers impair correct chromosome segregation in allopolyploids. Here the authors show that most non-homologous crossovers in Brassica napus arise from MSH4-dependent recombination and provide evidence that post-polyploidization reduction of MSH4 duplicate stabilizes meiosis.