International Journal of Molecular Sciences (May 2021)

Oral Bone Tissue Regeneration: Mesenchymal Stem Cells, Secretome, and Biomaterials

  • Agnese Gugliandolo,
  • Luigia Fonticoli,
  • Oriana Trubiani,
  • Thangavelu S. Rajan,
  • Guya D. Marconi,
  • Placido Bramanti,
  • Emanuela Mazzon,
  • Jacopo Pizzicannella,
  • Francesca Diomede

DOI
https://doi.org/10.3390/ijms22105236
Journal volume & issue
Vol. 22, no. 10
p. 5236

Abstract

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In the last few decades, tissue engineering has become one of the most studied medical fields. Even if bone shows self-remodeling properties, in some cases, due to injuries or anomalies, bone regeneration can be required. In particular, oral bone regeneration is needed in the dentistry field, where the functional restoration of tissues near the tooth represents a limit for many dental implants. In this context, the application of biomaterials and mesenchymal stem cells (MSCs) appears promising for bone regeneration. This review focused on in vivo studies that evaluated bone regeneration using biomaterials with MSCs. Different biocompatible biomaterials were enriched with MSCs from different sources. These constructs showed an enhanced bone regenerative power in in vivo models. However, we discussed also a future perspective in tissue engineering using the MSC secretome, namely the conditioned medium and extracellular vesicles. This new approach has already shown promising results for bone tissue regeneration in experimental models.

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