Clinical significance of PET-CT coronary flow reserve in diagnosis of non-obstructive coronary artery disease

BMC Research Notes. 2018;11(1):1-4 DOI 10.1186/s13104-018-3667-0

 

Journal Homepage

Journal Title: BMC Research Notes

ISSN: 1756-0500 (Online)

Publisher: BMC

LCC Subject Category: Medicine | Science: Biology (General) | Science: Science (General)

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Henry Anselmo Mayala (Department of Cardiology 10th floor, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology)
Khamis Hassan Bakari (Department of Radiology and Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology)
Fabian Pius Mghanga (Department of Internal Medicine, Archbishop James University College)
Wang ZhaoHui (Department of Cardiology 10th floor, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 15 weeks

 

Abstract | Full Text

Abstract Objective To improve current knowledge of coronary flow reserve and non-obstructive coronary artery disease in terms of definition, features and clinical implications of measurement of coronary flow reserve (CFR), is an integrated measure of focal, diffuse, and small vessel coronary artery disease, can also be explained as a calculated ratio of hyperaemic to rest absolute myocardial blood flow. Non-obstructive coronary artery disease is defined as atherosclerotic plaque that does not obstruct blood flow or result in anginal symptoms. We also aimed at knowing the significance of PET in diagnosing coronary microvascular disease. Results In our study 92% were between 41 and 60 years. 83% were males and 17% females, more patients had hypertension about 50%, few had diabetes mellitus about 16%, while those with both hypertension and diabetes mellitus were 17%. About 83% had ST segment and T wave changes on ECG. All patients and controls had normal coronaries on coronary angiography TIMI 3 flow. On further investigation by Positron emission tomography/CT we found out 58% had abnormal CFR and 42% had normal coronary flow reserve. Our findings indicate PET/CT coronary flow reserve concept provides a platform for the diagnosis of non-obstructive coronary artery disease in patients with signs and symptoms of ischemia without angiographic obstructive CAD.