Nature Communications (Sep 2018)
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
- Gareth J. Inman,
- Jun Wang,
- Ai Nagano,
- Ludmil B. Alexandrov,
- Karin J. Purdie,
- Richard G. Taylor,
- Victoria Sherwood,
- Jason Thomson,
- Sarah Hogan,
- Lindsay C. Spender,
- Andrew P. South,
- Michael Stratton,
- Claude Chelala,
- Catherine A. Harwood,
- Charlotte M. Proby,
- Irene M. Leigh
Affiliations
- Gareth J. Inman
- Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee
- Jun Wang
- Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London
- Ai Nagano
- Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London
- Ludmil B. Alexandrov
- Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego
- Karin J. Purdie
- Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Richard G. Taylor
- Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee
- Victoria Sherwood
- Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee
- Jason Thomson
- Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Sarah Hogan
- Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Lindsay C. Spender
- Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee
- Andrew P. South
- Department of Dermatology and Cutaneous Biology, Thomas Jefferson University
- Michael Stratton
- Cancer Genome Project, Wellcome Trust Sanger Institute
- Claude Chelala
- Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London
- Catherine A. Harwood
- Centre for Cell Biology and Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Charlotte M. Proby
- Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee
- Irene M. Leigh
- Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee
- DOI
- https://doi.org/10.1038/s41467-018-06027-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated with chronic exposure to the immunosuppressive drug azathioprine.
