A NEW COMBINATION INHIBITS INTESTINAL CHOLESTEROL ABSORPTION, SUPPRESSES ENDOGENOUS CHOLESTEROL SYNTHESIS, AND DEMONSTRATES ANTI-INFLAMMATORY AND HEPATOPROTECTIVE EFFECTS

Abstract

Hypercholesterolemia (HCH) and vascular inflammation are the main therapeutic targets in atherosclerosis. The paper discusses the results of the studies which have focussed on the effects of a new class of physiologically active substances (polyprenols and β-sitosterols) on lipid profile and pro-inflammatory cytokines in HCH patients with low to moderate cardiovascular risk. Polyprenol phosphates and phytosterols could help to achieve significant changes in lipid profile and normalisation of immunologic parameters.

Keywords

• atherosclerosis
• inflammation
• dyslipidaemia
• pro-inflammatory cytokines
• polyprenol phosphates
• phytosterols